evaluation of anti-inflammatory and analgesic activity of root extract of solanum trilobatum linn
نویسندگان
چکیده
methanolic extract of solanum trilobatum linn. (mest) belonging to the family of solanacea was evaluated by hot plate and acetic acid induced writhing methods to assess its analgesic activity. the extract was also evaluated for its anti-inflammatory activity by subjecting into carrageenan, and cotton pellet induced granuloma tests for its effect on acute and chronic phase inflammation models in rats, as well as analgesic activity in mice. it was found that the extract caused an inhibition on the writhing response induced by acetic acid in a dose dependent manner. 300 mg/kg doses of mest and indomethacin could block the writhing response by 46.68% and 73.73% (p<0.05), respectively. it was also indicated that the mest showed significant (p<0.001) antinociceptive action in hot plate reaction time method in mice. this effect was comparable to that of standard drug pentazocine treated controls, suggesting the central activity of mest. maximum inhibition (56.71%) was obtained at a dose of 100 mg/kg after 3 h of drug treatment in carrageenan induced paw oedema, whereas indomethacin (standard drug) produced 57.65% of inhibition. in the chronic model (cotton pellet induced granuloma) the mest 300 mg/kg, indomethacin and dexamethasone standard drug showed decreased formation of granuloma tissue by 21.48%, 29.63% and 34.84%, respectively. the results indicate the potent analgesic and anti-inflammatory effects and therapeutic efficacy of solanum trilobatum extract on animal models which are comparable with those of standard drugs such as pentazocine, indomethacin and dexamethasone, respectively.
منابع مشابه
Evaluation of Anti-inflammatory and Analgesic Activity of Root Extract of Solanum Trilobatum Linn
Methanolic extract of Solanum trilobatum Linn. (MEST) belonging to the family of Solanacea was evaluated by hot plate and acetic acid induced writhing methods to assess its analgesic activity. The extract was also evaluated for its anti-inflammatory activity by subjecting into carrageenan, and cotton pellet induced granuloma tests for its effect on acute and chronic phase inflammation models in...
متن کاملEvaluation of Anti-inflammatory and Analgesic Activity of Root Extract of Solanum Trilobatum Linn
Methanolic extract of Solanum trilobatum Linn. (MEST) belonging to the family of Solanacea was evaluated by hot plate and acetic acid induced writhing methods to assess its analgesic activity. The extract was also evaluated for its anti-inflammatory activity by subjecting into carrageenan, and cotton pellet induced granuloma tests for its effect on acute and chronic phase inflammation models in...
متن کاملEvaluation of Anti-inflammatory Activity of the Leaf Extracts of Solanum Trilobatum Linn
Methanol extracts of Solanum trilobatum Linn Leaf were investigated for anti-inflammatory activity with acute and chronic models. In the doses of 100, 200 and 300 mg kgexhibited significant (P < 0.05) anti-inflammatory activity in all the models tested. The methanol extracts of Solanum trilobatum Linn at 300 mg kg showed maximum inhibition of 54.44 % in carrageenan-induced rat paw oedema while ...
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چکیده بررسی فعالیت ضد اکسیدانی و ضدمیکروبی عصاره گیاه بن سرخ (allium jesdianum) به کوشش: زهرا مقیمی هدف از این تحقیق بررسی میزان ترکیبات فنولی کل، ترکیبات فلاوونوئیدی کل، فعالیت ضداکسیدانی و ضدمیکروبی عصاره ی گیاه تازه و خشک بن سرخ بود. استخراج عصاره به روش های غوطه وری، استفاده از همزن مغناطیسی، دستگاه مایکروویو، امواج فراصوت و گرمادهی مقاومتی و با استفاده از متانول، اتانول و آب به عنوا...
Acute and sub-chronic toxicological evaluation of ethanol extract of Solanum trilobatum Linn.
Background and objectives: Solanum trilobatum plant parts such as berries and flowers are normally used for the treatment of respiratory illnesses. The toxicity profile of the plant and its parts are not clear. Hence, the present study was planned to investigate the toxicological effects of ethanol extract of leaves of S. trilobatum (EEST) using acute and sub-...
متن کاملAnti-inflammatory activity of leaf extract of Solanum anomalum
Background & Aim: Solanum anomalum Thonn. ex Schumach. (family Solanaceae) is a shrub growing up to 2 metres tall. The edible fruits are gathered from the wild and consumed locally and the leaves are used locally in the treatment of various diseases. Evaluation of anti-inflammatory activity of leaf extract of Solanum anomalum was carried out to ascertain its uses in t...
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عنوان ژورنال:
iranian journal of pharmaceutical researchجلد ۲۰۰۸، شماره ۷، صفحات ۲۱۷-۲۲۱
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